FREE
SHIPPING!

on all orders above $300.00

FREE Pills!

via4gra pills

for free with every order

OUR DRUG PRICES are

70%

Less than in your
local pharmacy

Search by letter:

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Moduretic (Amiloride hydrochlorothiazide)
+ BONUS

Rating of sales:          

 
Moduretic

Moduretic is used for treating fluid retention (edema) and high blood pressure. It may be used alone or with other medicines.

Other names for this medication:
Acesistem, Acortiz, Acuren, Adelphan, Aldoril, Altace hct, Amiloretic, Ampril hd, Angiozide, Aquazide, Aratan-d, Belsar plus, Benalapril plus, Benazeplus, Berlipril, Beta-turfa, Bifril plus, Bifrizide, Bihasal, Bisobeta comp, Bisocombin, Bisohexal plus, Bisolich comp, Bisoplus, Bisostad plus, Bitensil diu, Blopress plus, Bpzide, Briazide, Bumeftyl, Byol, Capto-corax comp, Capto-isis plus, Captobeta comp, Captogamma hct, Captosol comp, Cardace comp, Cesplon plus, Cibadrex, Cilazil, Clorana, Co aprovel, Co diovan forte, Co renitec, Co-amilozide, Co-enac hexal, Co-enalapril, Co-enatec, Co-epril, Co-inhibace, Co-lisinopril, Co-lisinostad, Co-mepril, Co-quinapril, Co-renistad, Co-renitec, Co-reniten, Coepratenz plus, Comilorid-mepha, Concor plus, Condiuren, Cordinate plus, Corodil comp, Corodin d, Corvo hct, Cosaar, Coteveten, Crinoretic, Dehydratin, Dehydratin neo, Di-ertride, Di-eudrin, Dichlotride, Diclotride, Dilabar diu, Disalunil, Disothiazide, Disys plus, Ditenside, Dithiazide, Diu venostasin, Diunorm, Diur, Diurace, Diuretidin, Diuretikum verla, Do-hydro, Dociteren, Drenol, Duopril, Duradiuret, Dynacil comp, Dynorm plus, Dytenzide, Dytide, Ednyt hct, Elektra, Elpradil hct, Emconcor comp, Emcoretic, Emestar plus, Enacecor, Enacomi, Enahexal comp, Enala-q comp, Enalagamma hct, Enalich comp, Enap-co, Enaplus, Enulid 15, Epratenz, Epratenzide plus, Epril plus, Eprosartan, Eprotan, Esidrex, Esidrix, Femipres plus, Fempress plus, Fosicard plus, Fosicomb, Fosicombi, Fosicomp, Fosinopril, Fosinorm comp, Fositens plus, Fozide, Foziretic, Futuran plus, Gamathiazid, Gentipress, Gliotenzide, Herten plus, Hexal-lisinopril, Hexazide, Hidroclorotiazida, Hidroronol, Hidrosaluretil, Hidrotiadol, Hiperlex plus, Hipoartel plus, Hydra-zide, Hydrene, Hydrex, Hydrodiuril, Hydromet, Hydrozide, Hypodehydra, Hypothiazid, Inderide, Inhibace, Inibace plus, Initiss plus, Inocar plus, Iperton, Irtan plus, Isoptin rr plus, Ixia plus, Kalpress plus, Konveril plus, Labodrex, Lidaltrin diu, Linatil comp, Lisi tad hct, Lisi-puren comp, Lisibeta comp, Lisigamma hct, Lisihexal comp, Lisiplus, Lisoretic, Lispirl, Lodoz, Logroton retard, Loortan plus, Loren-press, Lorzaar, Losapot-h, Losar-q comp, Losar-tevacomp, Losargamma hct, Losarplus al, Losartas ht, Losatan hz, Losatrix comp, Losavik-h, Lotrial d, Maxsoten, Medozide, Mencord plus, Meramyl hct, Meto-succinat hct, Metobeta comp, Metodura comp, Metohexal comp, Metostad comp, Microzide, Miten plus, Modrex, Monoplus, Monopril, Monozide, Navixen plus, Nefrix, Neo lotan plus, Neoprex, Neotensin diu, Nephral, Newtolide, Nolarmin, Normolose-h, Nu-triazide, Olina, Olinapril h, Olmax-h, Openvas plus, Oretic, Pantemon, Parapres plus, Pharmapress co, Pressitan plus, Prestole, Pritor plus, Propra, Quinaplus, Quinaretic, Quiril comp, Ramasar hct, Rasilez hct, Regulaten plus, Renacor, Renapril plus, Renezide, Renil hct, Reniten plus, Rethizid, Ridaq, Rofucal, Sarilen plus, Sarteg hct, Sectrazide, Selokomb, Synerpril, Tandiur, Tekturna hct, Tevafos, Tevanap, Tevetec, Teveten plus, Tevetens plus, Tiaren, Tiazid, Timolide, Tri-thiazid, Triamizide, Triampur, Triamtereen, Triamteril, Triastad hct, Triatec comp, Triniton, Tritace comp, Tritace hct, Turfa, Uniretic, Urirex k, Vaseretic, Votum plus, Wytens, Zaprace-d, Zapto-co, Ziak, Zofenil diu, Zofenil plus, Zofenilduo, Zok-zid, Zopranol diu, Zoprazide

Similar Products:
Lasix, Norvasc, Toprol, Hyzaar, Cozaar, Frumil, Diovan

30 pills
 
When you purchase you get a bonus:
Cialis Soft
Cialis Soft 20mg
or Viagra Soft
Viagra Soft 100mg

You can choose your bonus in the shopping cart before checkout.

 
   bonus pills

  $20

  $30

USD 1.52 per pill   -20% USD 57.10 USD 45.68 per 30 pills   Order now
60 pills
 
When you purchase you get a bonus:
Cialis Soft
Cialis Soft 20mg
or Viagra Soft
Viagra Soft 100mg

You can choose your bonus in the shopping cart before checkout.

 
   bonus pills

  $20

  $30

USD 1.16 per pill   -20% USD 86.63 USD 69.30 per 60 pills   Order now
90 pills
 
When you purchase you get a bonus:
Cialis Soft
Cialis Soft 20mg
or Viagra Soft
Viagra Soft 100mg

You can choose your bonus in the shopping cart before checkout.

 
   bonus pills

  $20

  $30

USD 1.09 per pill   -20% USD 122.85 USD 98.28 per 90 pills   Order now
120 pills
 
When you purchase you get a bonus:
Cialis Soft
Cialis Soft 20mg
or Viagra Soft
Viagra Soft 100mg

You can choose your bonus in the shopping cart before checkout.

 
   bonus pills

  $20

  $30

USD 1.07 per pill   -20% USD 160.65 USD 128.52 per 120 pills   Order now
180 pills
 
When you purchase you get a bonus:
Cialis Soft
Cialis Soft 20mg
or Viagra Soft
Viagra Soft 100mg

You can choose your bonus in the shopping cart before checkout.

 
   bonus pills

  $20

  $30

USD 1.05 per pill   -20% USD 236.25 USD 189.00 per 180 pills   Order now

Also known as:  Amiloride hydrochlorothiazide.

Description

Moduretic is a diuretic (water pill) and a combination of a potassium-sparing diuretic (amiloride) and a thiazide diuretic (hydrochlorothiazide). It works by making the kidneys eliminate sodium (salt) and water from the body, which helps to lower blood pressure. The amiloride component helps minimize potassium loss.

Brand name of Moduretic is Moduretic.

Dosage

Take Moduretic by mouth with food.

Moduretic may increase the amount of urine or cause you to urinate more often when you first start taking it. To keep this from disturbing your sleep, try to take your dose before 6 pm.

If you want to achieve most effective results do not stop taking Moduretic suddenly.

Overdose

If you overdose Moduretic and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Do not freeze. Keep container closed tightly. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Moduretic are:

  • moduretic tablets
  • moduretic drug information
  • moduretic cost
  • moduretic online
  • moduretic generic name
  • moduretic drug
  • moduretic buy online
  • moduretic tab
  • moduretic 5mg tablet
  • moduretic dosage
  • moduretic drug class
  • moduretic tablet
  • moduretic online kaufen
  • moduretic pills
  • moduretic tablet dosage
  • moduretic tablets dose
  • moduretic buy
  • moduretic online purchase
  • moduretic tablet indication
  • moduretic drug interactions
  • moduretic tablets uses
  • moduretic maximum dose
  • moduretic tablet kullananlar
  • moduretic reviews
  • moduretic generic
  • moduretic dosage bodybuilding
  • moduretic medicine
  • moduretic 50 mg
  • moduretic tabs
  • moduretic dose
  • moduretic fluid tablets
  • moduretic tablets dosage
  • moduretic medication
  • moduretic 40 mg
  • moduretic tablets used
  • moduretic overdose
  • moduretic dosage dogs
  • moduretic 25 mg
  • moduretic 30 tablet

Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Moduretic if you are allergic to Moduretic components or to any ingredient in Moduretic or any other sulfonamide (eg, sulfamethoxazole).

Be careful with Moduretic if you're pregnant or you plan to have a baby, or you are a nursing mother.

Be careful with Moduretic if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement.

Be careful with Moduretic if you have allergies to medicines, foods, or other substances.

Be careful with Moduretic if you have cirrhosis or liver problems, diabetes, gout, kidney problems or kidney stones, asthma, heart problems, or systemic lupus erythematosus.

Be careful with Moduretic if you have elevated blood acid, low folic acid levels, or electrolyte problems, or are dehydrated.

Be careful with Moduretic if you take potassium-sparing diuretics (eg, spironolactone), potassium supplements, or salt substitutes containing potassium because high blood potassium levels may occur and cause listlessness, confusion, abnormal skin sensations of the arms and legs, heaviness of limbs, slowed heart rate, irregular heart rhythm, or stopping of the heart; cholestyramine or colestipol because they may decrease Moduretic 's effectiveness; nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, indomethacin) because they may decrease Moduretic 's effectiveness and risk of kidney problems may be increased; barbiturates (eg, phenobarbital), certain chemotherapy medicines, corticosteroids (eg, prednisone), digoxin, dofetilide, ketanserin, narcotic pain medicines (eg, codeine), or medicines for high blood pressure because the risk of their side effects may be increased by Moduretic; diazoxide, lithium, or nondepolarizing neuromuscular blockers (eg, pancuronium) because their actions and the risk of their side effects may be increased by Moduretic; angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril) because the risk of high blood potassium and kidney problems may be increased by Moduretic; diabetes medicines (eg, glipizide) or insulin because their effectiveness may be decreased by Moduretic.

Do not stop taking Moduretic suddenly.

moduretic cost

Acute effects of amiloride (5 mg) (A), hydrochlorthiazide (50 mg) (H) and the combination (50 + 5 mg) (HA) on urinary electrolyte excretion and pH of ten healthy volunteers--taking placebo five times and twice randomly A and HA and once H--were studied during one day. Amiloride showed a natriuretic effect, which in combination was additive to that of hydrochlorthiazide, but the excretion of water did not increase significantly after A. The urinary excretion of potassium decreased with amiloride below normal levels and was at the level of placebo after the combination (HA). There was a striking linear correlation between urinary sodium and potassium with all the drugs, although showing with A a higher potassium retention during high sodium excretion. Urinary pH rose after A and HA during the first 8 hours, but this effect was not seen, however, after H. No significant differences in the effect of the two brands of A (Medamor and Puritrid) on the urinary electrolyte excretion and pH, nor in those of the two brands of HA (Moduretic and Amitrid) were found. Similarly, the plasma concentrations of hydrochlorthiazide, determined gas chromatographically, were equal after Moduretic and Amitrid tablets. The systemic availability of H was faster in the combination of HA than alone. In the AUC value of H, however, there was no significant difference between HA and H tablets.

moduretic dosage

The pharmacological treatment, mainly based on diuretics, of isolated systolic hypertension (ISH) has recently been shown to reduce the risk of stroke and coronary heart disease in the elderly. The purpose of this study was to compare the antihypertensive effect and tolerability of different drug regimens in elderly subjects with ISH (systolic blood pressure--SBP-- > or = 160 mmHg and diastolic blood pressure--DBP-- < 90 mmHg). A multicentre, randomized, controlled open trial was planned in the general practice setting. Four widely used treatment schedules were tested: hydrochlorothiazide 25 mg plus amiloride 2.5 mg (H+Am), nifedipine slow release 20 mg (N), atenolol 50 mg (At) and atenolol 25 mg plus chlorthalidone 6.25 mg (At+C). After a baseline evaluation, 308 patients (76.3% female, mean age 75.3 +/- 7.1 years) were randomized and followed up for 6 months. After 3 months the drug dosage was doubled if the systolic blood pressure goal (SBP < 160 mmHg and SBP reduction of at least 20 mmHg) had not been reached. Ninety-four subjects (30.5%) presented contraindications to beta-blockers. At the 3rd- and 6th-month visits all treatment groups, except At, showed a significant reduction in SBP compared to the control group; DBP showed no significant reduction in any group at any time. At the end of the follow-up the percentage of hypertensives who had reached the BP goal was 14.6% in the control group, 52.9% in H+Am, 54.8% in N, 28.6% in At and 52.2% in At+C.(ABSTRACT TRUNCATED AT 250 WORDS)

moduretic overdose

In a randomized double blind study 100 men (mean age 46 (22-64) years) with mild to moderate hypertension were followed every 3rd month for one year. Fifty were randomized to atenolol 50 mg and 50 to hydrochlorothiazide 25 mg+amiloride 5 mg (co-amiloride) once daily. The doses were doubled at 3 or 6 months if diastolic blood pressure (DBP) remained > or = 95 mmHg. If DBP was > or = 95 mmHg even at 6 or 9 months, patients were classified as non-responders, and nifedipine 20 mg b.i.d. was added. After one year 31/50 randomized to atenolol and 17/50 randomized to co-amiloride had responded to monotherapy (p < 0.05). Neither clinical findings nor haemodynamic measurements by Doppler at baseline could distinguish between co-amiloride responders and non-responders. Conversely, non-responders to atenolol as compared with atenolol responders had higher body weight (p = 0.02), higher systolic BP (p = 0.03), higher DBP (p = 0.009), stroke volume (p = 0.04), and cardiac output (p = 0.0002) combined with lower total systemic vascular resistance (p = 0.02). This suggests that some were apparent non-responders due to too low dosing of atenolol rather than true non-responders. Measurements of haemodynamics may be of importance in the assessment of optimal antihypertensive therapy according to baseline and follow-up haemodynamic aberrations.

moduretic 30 tablet

A national multicenter study (34 centers) compared six treatments in 328 patients with cirrhotic ascites. Excluded were patients with g.i. bleeding within the last six months, chronic encephalopathy, cancer, tuberculosis or the following complications persisting after three weeks: acute encephalopythy, fever greater than 38 degrees C, infected ascites or biochemical abnormalities: blood urea greater than 8 mmol/l, natremia less than 130 mmol/l, kaliemia less than 2.5 or greater than 5.5 mmol/l, WBC greater than 12000 mm3, total bilirubin greater than 85.5 mumol/l. In each center patients were randomized into two treatment groups, each center using 2 of 6 proposed treatments: (1) Spironolactone and 500 mg Na p.d (77 patients), (2) Spironolactone + furosemide or Moduretic (amiloride + hydrochlorothiazide) and 500 mg Na p.d (80 patients), (3) Spironolactone + Furosemide or Moduretic and unrestricted sodium diet (86 patients), (4) Concentrated ascites reinfusion and 500 mg Na p.d. (36 patients), (5) Unmodified ascites reinfusion and 500 mg Na p.d. (23 patients), (6) Slow ascites drainage and 500 mg Na p.d. (31 patients). Statistical analysis methods were X2, variance analysis and Spotvoll-Stoline and Dunn-Sidak tests. Before treatment, there was no significant difference between the 6 groups.

moduretic online kaufen

Diurexan (xipamide) 40 mg daily was substituted for Navidrex-K (cyclopenthiazide 0.25 mg plus potassium 600 mg) or Moduretic (amiloride hydrochloride 5 mg plus hydrochlorthiazide 50 mg) in nineteen patients with oedema of cardiac origin. Comparative efficacy and patient acceptability were examined over a 4-week treatment period. In six patients their oedema was resolved and in a further seven their oedema was markedly reduced (six patients had no overt oedema pre-trial). The body-weight of nine patients decreased by an average of 1.4 kg whilst in seven patients it remained static and in three patients it increased by an average of 1.8 kg. Thirteen of the patients preferred Diurexan at the end of the 4-week trial period, four patients had no preference and two patients preferred their previous treatment.

moduretic drug class

A cross-over study, comparing the effects of doxazosin, moduretic and amlodipine on plasma lipid and lipoprotein levels in 9 hypertensive Nigerians aged 35 to 65 years is presented. Doxazosin therapy had favourable lipid changes characterized by a statistically significant reduction in total cholesterol (TC) at 6 months. Though consistent reduction was observed in total triglycerides (TG) low density lipoprotein cholesterol (LDL-C), very low density lipoprotein-cholesterol (VLDLC) upto 6 months, no effect was seen on high density lipoprotein cholesterol (HDLC). This is against unfavourable increments in the mean values of TC, VLDLC, LDLC/HDLC and decrease in HDLC/TC during moduretic treatment phase. Amlodipine therapy did not alter the lipid and lipoprotein levels. The non-significant variation in the mean high density lipoprotein-cholesterol (HDLC) level observed with these agents, seem to suggest that HDL-cholesterol metabolism may be maintained during antihypertensive pharmacotherapy.

moduretic tablets dosage

27 patients with essential hypertension received placebo for 2 weeks, then 1 Moduretic tablet (50 mg hydrochlorothiazide and 5 mg amiloride) daily for 4 weeks, followed by 2 Moduretic tablets daily for a further 10 weeks. The average systolic and diastolic reductions were 26.3/14.0 mm Hg standing and 27.8/19.7 mm Hg lying. 17 of the 27 patients were treated before the beginning of the study with 100 mg hydrochlorothiazide or an equivalent preparation. After 14 weeks' therapy with Moduretic the average systolic/diastolic fall in pressure in these 17 patients was 18.5/9.9 mm Hg standing and 21.6/14.3 mm Hg lying, which was lower than with a thiazide monotherapy. No cases of hyperkalemia or hypokalemia were observed. Moduretic lowers the blood pressure considerably more than thiazide alone and without any concomitant danger of hypokalemia.

moduretic medication

The clinical pharmacology of the diuretic amyloride was studied in 60 patients suffering from circulatory insufficiency of various origin. Midamor and moduretic of the "Merck" firm (USA) were used in a dose of 1 to 4 tablets. The duration of treatment was from 3 days to 18 months. It was found that under the effect of amyloride natriuresis increases moderately in patients with circulatory insufficiency with no simultaneous increase in the loss of potassium with the urine. As the circulatory insufficiency becomes more severe, the natriuretic and potassium-saving effect of the drug diminishes. Amyloride potentiates the diuretic and natriuretic effect of furosemide and hydrochlorothiazide well without increasing kaliuresis. In patients in whom the disease is less severe, two-week treatment with amyloride leads to an authentic increase in the total metabolic potassium in the organism. The patients tolerate the drug well. It is recommended for wide clinical use.

moduretic fluid tablets

Calcium controls numerous events within the vessel wall. Permeability of the endothelium is calcium dependent, as are platelet activation and adhesion, vascular smooth muscle proliferation and migration, and synthesis of fibrous connective tissue. Double-helix computerized tomography is a noninvasive technique that can detect, measure, and compare coronary calcification in the coronary arteries. Using this method, our objective was to determine whether administration of nifedipine once daily in lieu of diuretics in high-risk hypertensive patients will arrest or slow down the progression of coronary artery calcification. The study was designed as a side arm of INSIGHT (International Nifedipine Study: Intervention as Goal for Hypertension Therapy), aimed to show the efficacy of nifedipine once daily versus co-amilozide (hydrochlorothiazide 25 mg, amiloride 2.5 mg) in high-risk hypertensive patients. A total of 201 patients with a total calcium score of >/=10 at the onset of study who underwent an annual double-helix computerized tomography for 3 years were analyzed for efficacy. Inhibition of coronary calcium progression was significant in the nifedipine versus the co-amilozide group during the first year (3.18% versus 27%, respectively, P=0.02), not significant during the second year (28.5% versus 47%, respectively, P=0.14), and significant during the third year (40% versus 78%, respectively, P=0.02). The results point to a slower progression of coronary calcification in hypertensive patients on nifedipine once daily versus co-amilozide.

moduretic tablets

In a multicenter open-label clinical trial, eligible patients were randomized to receive treatment with amlodipine 2.5-5 mg plus amiloride/hydrochlorothiazide 1.25-2.5 mg/12.5-25 mg (Group A) or amlodipine 2.5-5 mg plus telmisartan 40-80 mg (Group T). If a target BP was not reached, other antihypertensive agents would be added. The target BP was <130/80 mmHg for patients with diabetes mellitus or chronic kidney disease and <140/90 mmHg for others. Efficacy variables were changes from baseline in systolic BP and diastolic BP at the endpoint of 96 weeks. Safety evaluations included monitoring of any adverse events (AEs).

Target Point Shipping Method Tracking Delivery Time Price
Worldwide shipping

Worldwide shipping

Registered Mail  Not trackable 14-21 business days USD 20.00 per order
EMS  Trackable, where available 5-9 business days USD 30.00 per order

Delivery time is:

Registered Mail - 14-21 business days, prices - USD 20.00, no signature is required on delivery.
EMS - 5-9 business days, prices - USD 30.00, signature is required on delivery.
Your order will be packed safe and secure and dispatched within 24 hours.

front back side

This is exactly how your parcel will look like (pictures of a real shipping item). It has a look of a regular private letter and does not disclose its contents. Size - 9.4x4.3x0.3 inches (24x11x0.7cm).

Testimonials
Best
 Show Hide 
moduretic dosage dogs 2015-07-22

In 75 patients with circulatory insufficiency of various degree the diuretic effect of moduretic was studied. In 25 of them besides the potassium and sodium metabolism and in 33 others, with a background of chronic ischemic disease of the heart and hypertensive disease, the state of the hemocoagulation Oxytrol Reviews system was investigated in the moduretic medication. In 24 patients with hypertensive disease of the I--IIA stage subject to study was the effect of moduretic on the arterial pressure, with this drug administered by mouth in doses of 3 to 1/2 tablet a day. The drug proved to have a marked duretic effect in patients with different degree of circulatory insufficiency. It increases sodium excretion with urine and retains potassium in the organism, without causing hyperkaliemia. In patients with circulatory insufficiency of the I degree the drug can provoke thrombogenesis and in cases of the IIA, IIB and III degree may be considered a drug of choice. Moduretic brings down the systolic and diastolic pressure in patients with hypertensive disease of the I and II stages.

moduretic tablets used 2017-06-28

We did a prospective, randomised, double-blind trial in Europe and Israel in 6321 patients aged 55-80 years with hypertension (blood pressure > or = 150/95 mm Hg, or > or = 160 mm Hg systolic). Patients had at least one additional cardiovascular risk factor. We randomly assigned patients nifedipine 30 mg in a long-acting gastrointestinal-transport-system (GITS) formulation (n=3157), or co-amilozide (hydrochlorothiazide 25 mg [corrected] plus amiloride 2.5 mg; n=3164). Dose titration was by dose doubling, and addition of atenolol 25-50 mg or enalapril 5-10 mg. The primary Micronase Generic Name outcome was cardiovascular death, myocardial infarction, heart failure, or stroke. Analysis was done by intention to treat.

moduretic maximum dose 2016-06-21

A double-blind study was carried out in 24 hypertensive patients with thiazide-induced hypokalaemia (serum potassium less than 3.2 mmol/l) to compare the effects of treatment with an amiloride/hydrochlorothiazide combination or hydrochlorothiazide alone. The study was divided into Symmetrel 100 Mg three phases: (i) potassium repletion (Weeks 0 to 4) with oral potassium chloride (40 mmol/day), (ii) stabilization (Weeks 4 to 6) of normokalaemia, and (iii) active drug treatment (Weeks 6 to 14), patients being allocated at random to receive one or other of the two treatments. Dosage was 2 tablets per day of the 5 mg amiloride plus 50 mg hydrochlorothiazide combination or of 50 mg hydrochlorothiazide alone. The results showed that blood pressure control was comparable in both treatment groups but hydrochlorothiazide alone caused a statistically significant reduction in serum potassium levels compared to the drug combination. Apart from 1 patient who developed hypokalaemia on hydrochlorothiazide alone, no other side-effects of treatment were reported.

moduretic 5mg tablet 2017-06-25

A national multicenter study (34 centers) compared six treatments in 328 patients with cirrhotic ascites. Excluded were patients with g.i. bleeding within the last six months, chronic encephalopathy, cancer, tuberculosis or the following complications persisting after three weeks: acute encephalopythy, fever greater than 38 degrees C, infected ascites or biochemical abnormalities: blood urea greater than 8 mmol/l, natremia less than 130 mmol/l, kaliemia less than 2.5 or greater than 5.5 mmol/l, WBC greater than 12000 mm3, total bilirubin greater than 85.5 mumol/l. In each center patients were randomized into two treatment groups, each center using 2 of 6 proposed treatments: (1) Spironolactone and 500 mg Na p.d (77 patients), (2) Spironolactone + furosemide or Moduretic (amiloride + hydrochlorothiazide) and 500 mg Na p.d (80 patients), (3) Spironolactone + Furosemide or Moduretic and unrestricted sodium diet (86 patients), (4) Concentrated ascites reinfusion and 500 mg Na p.d. (36 patients), (5) Unmodified ascites reinfusion and 500 mg Na p.d. (23 patients Prograf 1mg Cost ), (6) Slow ascites drainage and 500 mg Na p.d. (31 patients). Statistical analysis methods were X2, variance analysis and Spotvoll-Stoline and Dunn-Sidak tests. Before treatment, there was no significant difference between the 6 groups.

moduretic tablet 2015-08-06

Hydrochlorothiazide stimulates salt Seroquel 25 Mg intake without altering salivary or gustatory function. Amiloride reportedly reduces salivary sodium levels and salt taste. It was hypothesized that these unintended drug actions would be attenuated by concurrent use of these 2 diuretics. Normotensive adults (n = 23) were administered placebo for 2 weeks, active combination drug Moduretic for 4 weeks, and placebo again for 2 weeks in a double-blind protocol. Salivary flow, gustatory function and sodium intake were monitored at the end of each period, together with selected physiologic measures (i.e., plasma aldosterone, plasma renin activity, body composition, blood pressure and heart rate). No significant changes were observed for salivary flow, salt taste or sodium intake. These findings indicate that amiloride and hydrochlorothiazide used in combination can reduce drug effects that may compromise the efficacy of either drug when used alone.

moduretic medication 2016-03-11

In a randomized double blind study 100 men (mean age 46 (22-64) years) with mild to moderate hypertension were followed every 3rd month for one year. Fifty were randomized 2 Paracetamol Tablets to atenolol 50 mg and 50 to hydrochlorothiazide 25 mg+amiloride 5 mg (co-amiloride) once daily. The doses were doubled at 3 or 6 months if diastolic blood pressure (DBP) remained > or = 95 mmHg. If DBP was > or = 95 mmHg even at 6 or 9 months, patients were classified as non-responders, and nifedipine 20 mg b.i.d. was added. After one year 31/50 randomized to atenolol and 17/50 randomized to co-amiloride had responded to monotherapy (p < 0.05). Neither clinical findings nor haemodynamic measurements by Doppler at baseline could distinguish between co-amiloride responders and non-responders. Conversely, non-responders to atenolol as compared with atenolol responders had higher body weight (p = 0.02), higher systolic BP (p = 0.03), higher DBP (p = 0.009), stroke volume (p = 0.04), and cardiac output (p = 0.0002) combined with lower total systemic vascular resistance (p = 0.02). This suggests that some were apparent non-responders due to too low dosing of atenolol rather than true non-responders. Measurements of haemodynamics may be of importance in the assessment of optimal antihypertensive therapy according to baseline and follow-up haemodynamic aberrations.

moduretic cost 2017-01-25

Simultaneous administration of indomethacin and Moduretic ( Cefixime 400 Mg Merck Sharp & Dohme, USA, 5 mg of amiloride HCl, 50 mg hydrochlorothiazide) to a 78-yr-old patient resulted in severe hyperkalemia twice. When administered alone, neither drug significantly changed the normal serum potassium levels. Laboratory findings suggest an alteration of the internal balance of potassium as the main mechanism of this particular drug-induced hyperkalemia.

moduretic online purchase 2015-02-22

The efficacy and biochemical effects of two low-dose thiazide plus potassium-sparing diuretic preparations were compared in the treatment of elderly patients with stable, mild to moderate congestive heart failure. Sixty Reglan 10mg Tab patients (mean age 80 years) were randomly allocated to treatment with 1 tablet daily of either 25 mg hydrochlorothiazide/2.5 mg amiloride or 25 mg hydrochlorothiazide/50 mg triamterene. The dose was increased to 2 tablets daily if necessary, after 2 weeks, for a further 6 weeks. Patients' response to treatment was assessed at 2, 4 and 8 weeks using a simple clinical scoring system for signs and symptoms of their condition, and routine biochemical analysis was carried out at baseline and the end of treatment. One patient was withdrawn from the study due to a rash which was probably related to hydrochlorothiazide/amiloride treatment. A further 11 patients were excluded from the analysis because of intercurrent illness or inadequate records. Analysis of the results from 48 patients showed that both treatments resulted in an improvement in clinical score and weight reduction, with more than three-quarters of the patients responding to treatment. No serious biochemical disturbances occurred; in particular, no new cases of hyponatraemia (serum sodium less than 130 mmol/l) developed. Both preparations, therefore, were effective and tolerated forms of treatment for mild to moderate congestive heart failure in the elderly and there were no significant differences between them.

moduretic tablets dosage 2016-05-26

In order to determine how both diuretics affect water metabolism, we here compare the effects of a rechallenge with either amiloride-hydrochlorothiazide fixed association (AmHTZ; amiloride chlorhydrate 5 mg+hydrochlorothiazide 50 mg; Moduretic) or furosemide (F; 40 mg; Lasix) on water excretion in a 79 year old woman who was previously admitted for severe symptomatic hyponatremia secondary to a 5 days course of AmHTZ for systolic hypertension. After correction of initial hydromineral disturbances, a standard oral water load (WL; 20 mL per kg body weight) was administered before, during and after AmHTZ or F challenges.

moduretic drug interactions 2015-03-11

Patients were divided according to renin status. Low-renin patients were treated with an aldosterone inhibitor in a prospective, randomized, placebo-controlled, double-blind, cross-over study.

moduretic tablet indication 2017-12-04

After a run-in period of 8 weeks on a regimen of hydrochlorothiazide (HCT, median dosage 75 mg/day), patients with essential hypertension were randomly allocated to continued hydrochlorothiazide therapy (Group I) or additional treatment with amiloride (Group II, median dosage 15 mg/day, or 5 mg per 25 mg hydrochlorothiazide) for the following 12 weeks. Thereafter all the patients were changed to treatment with a fixed combination tablet containing 5 mg amiloride and 50 mg hydrochlorothiazide (Moduretic), keeping the thiazide dosage unchanged for an additional 12 weeks. In Group I patients there was no change in plasma potassium, total body potassium content or the renin-angiotensin-aldosterone system during the 12 weeks on HCT. When the treatment was changed to Moduretic, significant increases were found of 10% in plasma potassium and 3% in total body potassium content. No important stimulation of the renin-angiotensin-aldosterone system was found. In Group II patients addition of an average of 15 mg amiloride to the hydrochlorothiazide treatment led to significant increases in plasma potassium and total body potassium content of approximately 15% and 4%, respectively. There was also a significant increase in the plasma concentrations of renin, angiotensin II and aldosterone. Reducing the average dose of amiloride to 7.5 mg/day by use of Moduretic did not lead to decrease in plasma potassium or total body potassium content. Plasma concentrations of renin, angiotensin II, and aldosterone were decreased, but the individual changes varied markedly and no significant overall change was found.