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Nexium

Generic Nexium is the medication of high quality which is taken in treatment of GERD (gastroesophageal reflux disease), Zollinger-Ellison syndrome and other diseases which are connected with stomach acid. It is also taken to treat erosive esophagitis and to prevent its damage. It also can be combined with other drugs to prevent gastric ulcer.

Other names for this medication:
Alenia, Alton, Asector, Axagon, Axiago, Ceso, Cronopep, Emep, Esmolac, Esofag, Esofag-d, Esomac, Esomep, Esomeprazol, Esomeprazolum, Esomezol, Esonix, Esopra, Esopral, Esopran, Esoprax, Esoprazol, Esoral, Esorest, Esotac, Esotid, Esotrax, Esoz, Espram, Inexium, Izra, Izra-d, Lucen, Maxima, Maxpro, Nedox, Neksium, Neptor, Neutraflux, Nexe, Nexiam, Nexiam iv, Nexpro, Nexum, Nexx, Nuloc, Opton, Perprazole, Preso, Progut, Pronex, Raciper, Raciper-d, Sergel, Sompraz, Ulcratex, Zosec

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Also known as:  Esomeprazole.

Description

Generic Nexium is the medication of high quality which is taken in treatment of GERD (gastroesophageal reflux disease), Zollinger-Ellison syndrome and other diseases which are connected with stomach acid. It is also taken to treat erosive esophagitis and to prevent its damage. It also can be combined with other drugs to prevent gastric ulcer.

Generic Nexium is acting by reducing the acid formed in the stomach. It is proton pump inhibitors.

Nexium is also known as Esomeprazole, Esomiz, Sompraz, Zoleri, Lucen, Esopral, Axagon, Nexiam.

Generic name of Generic Nexium is Esomeprazole.

Brand name of Generic Nexium is Nexium.

Dosage

Take Generic Nexium orally at the same time every day.

Do not chew or crush the delayed-release capsule.

If you use Generic Nexium in the treatment of GERD you should take it for 4-8 weeks.

If you use Generic Nexium in the treatment of gastric ulcer you can take it together with other medicines for 10 days.

Take Generic Nexium once a day, one hour before a meal.

If you want to achieve most effective results do not stop taking Generic Nexium suddenly.

Overdose

If you overdose Generic Nexium and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Generic Nexium overdosage: nausea, feeling confusion, fast heartbeat, convulsions, dry mouth, flushing, blurred vision, short breathing, sweating, tremor, problems with coordination, dyspepsia, migraine, drowsy.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Nexium are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Generic Nexium if you are allergic to Generic Nexium components or to the other benzimidazole medicines (mebendazole (such as Vermox), albendazole (such as Albenza), omeprazole (such as Prilosec), lansoprazole (such as Prevacid), pantoprazole (such as Protonix) and to esomeprazole), rabeprazole (such as AcipHex).

Do not take Generic Nexium if you're pregnant or you plan to have a baby, or you are a nursing mother. Generic Nexium can harm your baby.

It can be used together with antibiotics.

Be careful with Generic Nexium if you suffer from or have a history of liver disease.

Be careful with Generic Nexium if you are taking such medicines as atazanavir (such as Reyataz); diazepam (such as Valium); a blood thinner (warfarin (such as Coumadin)); digoxin (such as Lanoxin, Lanoxicaps); iron (such as Feosol, Mol-Iron, Fergon, Femiron), ketoconazole (such as Nizoral).

Do not stop taking Generic Nexium suddenly.

nexium heartburn medicine

The intention-to-treat population comprised 991 patients (esomeprazole, N = 493; placebo, N = 498). Twenty-seven patients (5.4%) in the placebo group developed a gastric or duodenal ulcer during 26 weeks' treatment compared with eight patients (1.6%) in the esomeprazole group (life-table estimates: 6.2%vs 1.8%; P= 0.0007). At 26 wk, the cumulative proportion of patients with erosive esophagitis was significantly lower for esomeprazole versus placebo (4.4% and 18.3%, respectively; P < 0.0001). At 26 wk, esomeprazole-treated patients were more likely to experience resolution of heartburn, acid regurgitation, and epigastric pain (P < 0.05).

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This modified sequential therapy achieved an excellent eradication rate (>95%) in second-line treatment and the eradication rate appeared to be affected by metronidazole resistance.

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Proton pump inhibitors reduce ulcer recurrence in non-steroidal anti-inflammatory drug (NSAID) users, but their impact in at-risk ulcer-free patients using the current spectrum of prescribed agents has not been clearly defined. We assessed esomeprazole for ulcer prevention in at-risk patients (> or = 60 yr and/or ulcer history) taking NSAIDs, including COX-2 inhibitors. Such studies are particularly relevant, given that concerns regarding adverse cardiovascular outcomes among COX-2 inhibitor users may prompt re-evaluation of their use.

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Because of the efficacy of proton pump inhibitors (PPIs), their the use is increasing dramatically. The risk of adverse effects of short-term PPI therapy is low, but there are important safety concerns for potential adverse effects of prolonged PPI therapy. Findings from studies assessing the association between PPI use and bone mineral density (BMD) and/or fracture risk are contradictory. The aim of this study was to prospectively assess potential association of PPI treatment with the 12-month change in BMD of the lumbar spine, femur neck, and total hip. The study was performed in 200 PPI users and 50 PPI nonusers. Lumbar spine (L1-L4), femur neck, and total hip BMD were measured by dual-energy X-ray absorptiometry at the baseline and at 12 months. A total of 209 subjects completed the entire 12 months of the study and were included in the final analysis. A Wilcoxon signed-rank test showed that at 12 months PPI use was associated with statistically significant reductions in femur neck and total hip T scores (Z = -2.764, p = 0.005 and Z = -3.281, p = 0.001, respectively). A multiple linear regression analysis showed that only esomeprazole added significantly to the prediction of total lumbar spine and femur neck T scores (p = 0.048 and p = 0.037, respectively). Compared with the baseline, 12 months of PPI treatment resulted in lower femur neck and total hip BMD T scores. Among the four PPIs studied, esomeprazole was independently associated with significant reduction of BMD, whereas omeprazole had no effects on BMD. Considering the widespread use of PPIs, BMD screening should be considered in the case of prolonged PPI use.

nexium regular dose

The aim of this study was to assess whether the efficacy of proton pump inhibitors (PPI) therapy at a standard dose in esophageal acid control is affected by the presence of hiatus hernia in Chinese gastroesophageal reflux disease patients, and whether a higher dose of PPI is required for acid control.

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Studies of the increasing use of proton pump inhibitors (PPIs) have mainly focused on prevalent long-term use and associations with gastrointestinal morbidity and comedication. Little is known about non-medical characteristics of first-time users of PPI, and predictors of initiating long-term use of PPIs.

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Two randomized, double-blind, 4-week, multi-centre trials with identical methodology compared once-daily esomeprazole, 40 mg (n = 241) or 20 mg (n = 234), with placebo (n = 242) for the rigorous end-point of complete resolution of heartburn. Secondary end-points included the percentage of heartburn-free days and the time to first and sustained resolution of heartburn.

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The aim of this study was to assess the overall exposure, other pharmacokinetic (PK) properties, and tolerability of esomeprazole magnesium after repeated oral doses of 5, 10, and 20 mg in pediatric patients who had symptoms of gastroesophageal reflux disease (GERD).

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Esomeprazole has higher oral bioavailability and increased antimicrobial activity against Helicobacter pylori than omeprazole.

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There was no effect of concomitant use of esomeprazole and clopidogrel or omeprazole and clopidogrel on the inhibition assay, but platelet residual units and percentage inhibition showed statistically significant improvement after stopping lansoprazole in Chinese patients who were on chronic clopidogrel therapy. Clopidogrel resistance existed more frequently in the Chinese-American population examined, and was as high as 68% (+PPI) to 73% (-PPI).

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H pylori infection was cured in 118 of the patients who received levofloxacin triple therapy (90%; 95% confidence interval, 85%-95%) and 93 of the patients who received rifabutin triple therapy (88.6%; 95% confidence interval, 82%-95%). In each group, the cure rate did not differ significantly between patients infected with H pylori strains resistant to single or multiple antibiotics. Mild side effects occurred in 15.5% and 14.9% of patients resistant to single or multiple antibiotics, respectively, and self-limiting neutropenia was observed in 1 (0.7%) case.

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nexium 20 mg 2015-06-23

Study drugs were selected based on the lack of physical compatibility data with cisatracurium and their use in intensive care units. Test admixtures were prepared by mixing 2.5-mL samples of varying concentrations of calcium gluconate, diltiazem, esomeprazole, regular insulin, nicardipine, pantoprazole, and vasopressin with either 2.5 mL of normal saline 0.9% (control) or 2.5 mL of cisatracurium (experimental) to simulate a 1:1 Y-site ratio. Drug infusions were prepared at the maximum concentrations used clinically. Physical compatibility of the admixtures was determined by visual and turbidimetric assessments performed in triplicate immediately after mixing and at 15, 30, and 60 minutes. Visual incompatibility was defined as a change in color, the formation of haze or precipitate, the presence of particles, or the formation of gas in the experimental groups compared with the controls. Disturbances invisible to the naked eye Diflucan 1 Pill were determined by assessing changes in turbidity of experimental admixtures compared with the controls.

nexium dosage otc 2016-11-03

The overall eradication rate was 80.7% (109/135, 95% CI 73.3%-86.5%) in the intention-to-treat analysis. The presence of amoxicillin resistance (OR 6.83, 95% CI 1.62-28 Avodart Medication Dosage .86, P = 0.009) and prior sequential therapy (OR 4.77, 95% CI 1.315-17.3, P = 0.017), but not tetracycline resistance (tetracycline group), were associated with treatment failure. The eradication rates in patients who received clarithromycin-, levofloxacin- and tetracycline-based sequential therapies were 78.9% (15/19), 92.2% (47/51) and 71.4% (25/35) in strains susceptible to clarithromycin, levofloxacin and tetracycline, respectively.

nexium dosage newborn 2016-12-21

Different end-point measures may contribute to inconsistent therapeutic responses Risperdal Medicine in relief of laryngopharyngeal reflux (LPR) symptoms.

nexium tablet 40mg 2017-12-06

The increased AUC of esomeprazole with repeated dosing is probably due to a combination of a decreased first-pass elimination and a decreased systemic clearance Norvasc Generic Reviews .

nexium safe dose 2017-11-01

The LOTUS trial, a 5-year exploratory randomized, open, parallel-group trial conducted in academic hospitals in 11 European countries between October 2001 and April 2009 among 554 patients with well-established chronic GERD who initially responded to acid suppression. A total of 372 patients (esomeprazole, n = 192; LARS, n = 180) completed 5-year follow-up. Interventions Two hundred sixty-six patients were randomly assigned to Keflex 875 Mg receive esomeprazole, 20 to 40 mg/d, allowing for dose adjustments; 288 were randomly assigned to undergo LARS, of whom 248 actually underwent the operation.

nexium online pharmacy 2015-04-14

Sixty-nine GORD patients had methacholine inhalation challenge performed on them, and FEV1, exhaled NO and respiratory symptoms were measured at baseline, after a 3-month treatment with esomeprazole and 3 months after fundoplication. Primary outcome variable was dose-response slope (DRS), i.e. decline in FEV1 during methacholine challenge divided with the amount of methacholine administered (%/μmol). Pre-defined subgroup analysis was performed among those with concomitant Evecare Capsules Ingredients asthma (n = 12).

nexium tires review 2017-09-19

Among primary-care patients Artane 20 Mg receiving PPI therapy for GORD, switching to esomeprazole therapy impacts positively on treatment satisfaction and symptom control.

nexium overdose 2016-12-11

Clostridium difficile is a gram-positive, anaerobic, spore-forming, rod-shaped bacterium responsible for most of the hospital Glucophage Tabs -acquired diarrhea in developed countries. The organism received its name because it was difficult to isolate and grow in culture. Infections in the elderly have been associated with significant morbidity and mortality as well as prolonged hospitalization.

generic nexium reviews 2017-08-10

Patients with chronic laryngeal symptoms suggestive of LPR underwent twice-daily 40 mg esomeprazole treatment for 12 weeks. We used a 50% or more reduction in the primary laryngeal symptom at week 12, an empirical criterion Voltaren Generic , as an anchor to dichotomize the participants into two groups, and to establish a responder definition of the RSI score change. The optimal cutoff point of the RSI score change was determined on the basis of the maximal Youden index of the receiver operating characteristic analysis.

nexium standard dose 2015-11-15

To determine if 8 weeks of esomeprazole 20 mg daily would be adequate for both symptom resolution and Trandate Max Dose oesophagitis healing in Chinese patients and the predictive factors for the response.

nexium usual dosage 2016-02-24

To investigate a 1-week once-daily triple therapy with esomeprazole, moxifloxacin, and rifabutin for rescue therapy of Helicobacter pylori infection.

nexium prescription dosage 2017-05-07

Esomeprazole 40mg once daily is cost effective compared with omeprazole 20mg once daily in the acute treatment of patients with reflux oesophagitis; esomeprazole provides greater effectiveness at a lower cost.

nexium medication 2016-08-26

Prescribed worldwide to treat gastroesophageal reflux disease (GERD), the proton pump inhibitors (PPIs) not only relieve acid reflux-related symptoms more rapidly than standard-dose or high-dose histamine2 receptor antagonists but also accelerate the rate of esophageal healing. Five PPIs--omeprazole, esomeprazole, lansoprazole, rabeprazole, and pantoprazole--are currently labeled by the Food and Drug Administration. These agents share a common mechanism of action and rarely exhibit clinically important interactions with other hepatically metabolized medications or pH-dependent drugs. Except for lingering concern about their long-term use in Helicobacter pylori-positive patients, the PPIs produce relatively few adverse effects when administered for the short or long term. Because primary care physicians are generally the first to treat patients with GERD, they may find it helpful to expand their knowledge of the pharmacologic effects of the PPIs. With an eye toward this end, Dr Berardi presents a cogent overview of PPI pharmacodynamics, pharmacokinetics, efficacy, drug interactions, and safety.